Discover interferon (IFN) regulated genes using the INTERFEROME online database
Wednesday, 28 June - 2pm-3pm - Hudson Institute Building, Level 3, Board Rooms A&B
IFNs
were identified as antiviral proteins more than 50 years ago and since
then have been shown to regulate cell proliferation, survival, migration
and specialised functions. Consequently they are involved in numerous
homeostatic and pathological processes including infections, cancer,
autoimmunity, inflammation and metabolic disorders. These cytokines are
also used as therapeutics in diseases such as chronic viral infections,
cancer and multiple sclerosis. IFNs potentially regulate the
transcription of up to 2000 genes in an IFN subtype, dose, cell type and
stimulus dependent manner.
The
Interferome database integrates information from high-throughput
experiments to gain a detailed understanding of the various IFN
activated pathways that regulate subsets of genes, with the aim to
enhance our understanding of pathophysiological processes.
In this seminar Dr Ross Chapman, from the Centre for Innate Immunity and Infectious Diseases, will introduce you to the Interferome online database and demonstrate analysis tools available on this application.
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